Search results for "deficiency [Isoenzymes]"

AIDS and the Central Nervous System: Examining Pathobiology and Testing Therapeutic Strategies in the SIV-Infected Rhesus Monkey

1993

Cortical astrocytosis in juvenile rhesus monkeys infected with simian immunodeficiency virus

1993

The pattern of expression of GFAP immunoreactivity in astrocytes of the juvenile rhesus monkey cortex was examined following infection with simian immunodeficiency virus (SIV). Blocks of cerebral cortex plus subjacent white matter from saline- and formalin-perfused brain were examined by peroxidase-linked immunochemical and immunofluorescence staining of deparaffinized sections. Strong GFAP immunoreactivity was found in astrocytic cells in both uninfected and SIV-infected juvenile macaque in the subpial cerebral cortex and in subcortical white matter, where GFAP-positive cells were abundant. GFAP staining of cortical layers 2-6 on the other hand was weak or absent in three uninfected contro…

TRANSACTIONAL SEX, EARLY MARRIAGE, AND PARENT– CHILD RELATIONS IN A TANZANIAN SLUM

2016

Transactional sex has been recognized as a major factor in the persistence of HIV/AIDS in Sub-Saharan Africa, yet it also has implications for the persistence of poverty. Using interview data collected between 2010 and 2015, this article examines how Muslim families in Dar es Salaam are affected by transactional sexual behavior.1 Examined are motives for transactional sex, how poor families view the purpose of marriage, and religious teachings and cultural beliefs about the onset of adulthood. Familial strategies to ensure provision for daughters and to improve the family’s socio-economic situation are impeded by the fact that in a context of high unemploy ment, transactional sex of ten rep…

Marta Dillon y Joaquín Hurtado : crónicas de la enfermedad crónica. / Marta Dillon and Joaquín Hurtado: chronicles of a chronic disease

2017

Resumen: A través de la lectura de las crónicas sobre el VIH/sida de Marta Dillon y Joaquín Hurtado, analizo cómo estos autores narran la convivencia crónica con el VIH que les impone el aprendizaje de nuevas formas de gestionar la vida y de autorrepresentarse. Estudio las crónicas no solo como estrategias terapéuticas para lidiar con los profundos cambios corporales y emocionales que trae consigo el diagnóstico, sino también como estrategias políticas para incidir en la normalización y percepción social de la enfermedad como entidad crónica. La reescritura del cuerpo, consustancial al devenir crónico de la enfermedad, enfrenta a los autores a cuestionar la improductividad o incapacidad de …

El model de la sida i les seves víctimes / The AIDS model and its victims

2017

Resumen: En un moviment similar al que efectua Michel Foucault en analitzar la lepra i la pesta com a malalties model del poder disciplinari i del poder sobirà, l’objectiu serà presentar la sida com a malaltia model del biopoder. Es tracta d’analitzar com els mecanismes de poder i de saber que gestionen la sida responen a una determinada economia de poder, que ja no pot ser explicada a través del model binari de la lepra, ni del model pesat i geomètric de la pesta. Per aconseguir això, farem un breu recorregut pel concepte de biopoder i pel model de la lepra i de la pesta. Seguidament, presentarem les novetats del model de la sida. L’anàlisi es centrarà en els primers anys de la malaltia: f…

Monoclonal antibodies with subnanomolar affinity to tenofovir for monitoring adherence to antiretroviral therapies: from hapten synthesis to prototyp…

2020

Approximately 32 million people have died of HIV infection since the beginning of the outbreak, and 38 million are currently infected. Among strategies adopted by the Joint United Nations Programme on HIV/AIDS to end the AIDS global epidemic, the treatment, diagnosis, and viral suppression of the infected subjects are considered crucial for HIV prevention and transmission. Although several antiretroviral (ARV) drugs are successfully used to manage HIV infection, their efficacy strictly relies on perfect adherence to the therapy, which is seldom achieved. Patient supervision, especially in HIV-endemic, low-resource settings, requires rapid, easy-to-use, and affordable analytical tools, such …

Herbal hepatotoxicity: a hidden epidemic

2011

Complementary and alternative therapies, including herbal products, have become increasingly popular in the general population and among patients and physicians. Regulations and pharmacovigilance regarding herbal drugs are still incomplete and need to be improved. In fact, herbals are commonly marketed on the Internet, and in many countries they are sold as food supplements, which are beyond the control of drug regulatory agencies. In Europe and the U.S., reports of hepatotoxicity from these products, including those advertised for liver diseases, are accumulating. Many herbal drugs are also commonly used in children, and in women during pregnancy and lactation, because they are believed to…

The 2-5A System and HIV Infection

1994

The human immunodeficiency virus type 1 (HIV-1) is the etiologic agent of acquired immunodeficiency syndrome (AIDS). The progression of this retro viral disease is associated with various clinical manifestations, including the acquisition of an immunodeficient state, the frequent presence of neurological disorders, and some malignancies (reviewed in Barre-Sinoussi et al. 1983; Wong-Staal and Gallo 1985; Fauci 1988). Immunologic dysfunctions caused by HIV-1 infection include disorders in the production of cytokines (Murray et al. 1984; Abb et al. 1986). For example, a significant decrease in the production of interferon-α (IFN-α) by cultured peripheral blood mononuclear cells (PBMC) from pat…

Health sector spending and spending on HIV/AIDS, tuberculosis, and malaria, and development assistance for health: progress towards Sustainable Devel…

2020

BACKGROUND: Sustainable Development Goal (SDG) 3 aims to "ensure healthy lives and promote well-being for all at all ages". While a substantial effort has been made to quantify progress towards SDG3, less research has focused on tracking spending towards this goal. We used spending estimates to measure progress in financing the priority areas of SDG3, examine the association between outcomes and financing, and identify where resource gains are most needed to achieve the SDG3 indicators for which data are available. METHODS: We estimated domestic health spending, disaggregated by source (government, out-of-pocket, and prepaid private) from 1995 to 2017 for 195 countries and territories. For …

Genetic basis of human complement C4A deficiency. Detection of a point mutation leading to nonexpression.

1993

Abstract The fourth component of the human complement system (C4) is coded for by two genes, C4A and C4B, located within the MHC. Null alleles of C4 (C4Q0) are defined by the absence of C4 protein in plasma. These null alleles are due either to large gene deletions or to nonexpression of the respective genes. In a previous study, evidence was obtained for nonexpressed defective genes at the C4A locus, and for gene conversion at the C4B locus. To further characterize the molecular basis of these non-expressed C4A genes, we selected nine pairs of PCR primers from flanking genomic intron sequences to amplify all 41 exons from individuals with a defective C4A gene. The amplified products were s…